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KMID : 0606920080160030231
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Biomolecules & Therapeutics
2008 Volume.16 No. 3 p.231 ~ p.236
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Anti-Inflammatory, Anti-Angiogenic and Anti-Nociceptive Activities of 4-Hydroxybenzaldehyde
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Lim Eun-Ju
Kang Hyun-Jung
Lim Chang-Jin
Jung Hyun-Joo
Kim Kyung-Hoon
Park Eun-Hee
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Abstract
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The current work was designed to assess novel pharmacological activities of 4-hydroxybenzaldehyde (HD), a major phenolic constituent of various natural products of plant origin, such as Gastrodia elata Blume. HD exhibited a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. HD also displayed an inhibitory effect in acetic acid-induced permeability in mice. Anti-nociceptive activity of HD was convinced using the acetic acid-induced writhing test in mice. HD was able to suppress production of nitric oxide (NO) and induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. HD also diminished the reactive oxygen species (ROS) level elevated in the LPS-activated macrophages. In brief, HD exhibits anti-angiogenic, anti-inflammatory and anti-nociceptive activities possibly via down-regulating iNOS and/or COX-2, which may be partly responsible for pharmacological efficacies of various natural products.
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KEYWORD
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Anti-angiogenic, Anti-inflammatory, Anti-nociceptive, Cyclooxygenase-2, 4-hydroxybenzaldehyde, Inducible nitric oxide synthase, Nitric oxide, RAW264.7, Reactive oxygen species
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